Phoenix WinNonLin

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Instructions

Tentative Pheonix WinNonLin Project

Task #1-Learn WinNonLin

Click for instructions here. You can stop at "Execute noncompartmental analysis"

  1. Make an MS Word docx document called Task01-Learning_Phoenix_WinNonLin.docx
  2. On the first page, describe what each of the abbreviations mean.
  3. Open Phoenix WinNonLin
  4. Create a new project called Task01-Learning_Phoenix_WinNonLin.phxproj
  5. Import dataset based on your student number such as Task01-Student01.dat
  6. Make a XY plot of your data (e.g., Task01-Student01.dat)
  7. Add the XY plot to one of the pages of your MS Word docx: Task01-Learning_Phoenix_WinNonLin.docx
  8. Make a table of your data.
  9. Add the table to one of the pages of your MS Word docx: Task01-Learning_Phoenix_WinNonLin.docx
  10. In Task01-Learning_Pheonix_WinNonLin.docx, and answer the following questions on the last page (Simple definitions please. Does not have to be complicated mathematics.):
    1. What is the difference between mean, harmonic mean, and geometric mean?
    2. What is the difference between standard deviation, standard error and pseudo standard deviation?
    3. What does coefficient of variation (CV%) mean in the context of this data?
    4. What does interquartile range (IQR) mean in terms of pharmacokinetics?
  11. Send Task01-Learning_Pheonix_WinNonLin.docx and Task01-Learning_Pheonix_WinNonLin.phxproj to me. You can email me directly from the remote desktop.

Tips, Additional Instructions, and Information

  1. The instructions are pretty good. The task takes about 1-2 hours.
  2. I recommend doing the example first.
  3. Change "Map Subject to the Stratification Row context." to "Map Subject to the Stratification Column context." because it is easier to read in MS Word 2013.
  4. The path is wrong in the instructions. The path should be C:\Program Files (x86)\Pharsight\Pheonix\application\Examples\Bguide1.dat
  5. This might be confusing, use the Microsoft Word 2013 that is on the Remote Desktop
  6. Right click on Figures to Copy them into Microsoft Word 2013
  7. Right click under Result Tables → Tables on the right. Then click Export... and save it somewhere where you can find it in html format. The default is table.html.
  8. Open the html file as a separate document and copy the table into the main document.
    1. You can find a lot of questions by going into Google and typing, "meaning of standard error" for the answer to question #2.
  9. If you are using Windows 10, you can paste directly back and forth between the Remote Desktop and your computer.
  10. Useful Links
    1. https://math.usask.ca/~laverty/S244/Lecture4.pdf

Student Data

Task #2-Fit Pharmacokinetics

Click for instructions here. You can stop at "Simulation and study design of PK models example"

  1. Make an MS Word docx document called Task02-Fit_Pharmacokinetics.docx
  2. On the first page of Task02-Fit_Pharmacokinetics.docx put a list of abbreviations and what they mean: tvKa, tvV, tvKe, stdev0, K01, K10, etc.
  3. Open Phoenix WinNonLin
  4. Create a new project called Task02-Fit_Pharmacokinetics.phxproj
  5. Import dataset based on your student number such as Task02-Student01.csv.
  6. Put he six plots on separate pages of Task02-Fit_Pharmacokinetics.docx
  7. Put the output data ⇒ results on a separate page of Task02-Fit_Pharmacokinetics.docx
    1. These should have values for tvKa, tvV, tvKe, stdev0, K01, K10
  8. In Task02-Fit_Pharmacokinetics.docx, describe what your results mean in a descriptive language.
  9. Send Task02-Fit_Pharmacokinetics.docx and Task02-Pharmacokinetics.phxproj to me.

Tips and Notes

  • The path of the example is wrong in the instructions. The path should be C:\Program Files (x86)\Pharsight\Pheonix\application\Examples\

Student Data

Task #3-Non-Compartment Analysis

Click for instructions herePDF Version

  1. Make an MS Word docx document called Task03-Non-Compartment_Analysis.docx
  2. On the first page of Task03-Non-Compartment_Analysis.docx, put the following parameters:
    1. Tau, Rsq_adjusted, MRTINF_pred, TimeLow, TimeBetween, TimeHigh, TimeInfBetween, Lamda Z
    2. Explain them in simple language. You can usually find them through a Google search.
  3. Open Phoenix WinNonLin
  4. Create a new project called Task03-Non-Compartment_Analysis.phxproj
  5. Import dataset based on your student number such as Task03-Student01.dat.
  6. Put a table of the results of one of the patients onto a page in Task03-Non-Compartment_Analysis.docx
  7. Put the NCA plot for the same patient onto a page of Task03-Non-Compartment_Analysis.docx
  8. Put the Final Parameters Pivoted onto a page of Task03-Non-Compartment_Analysis.docx
  9. Put the Ratios Differences onto a page of Task03-Non-Compartment_Analysis.docx
  10. In Task03-Non-Compartment_Analysis.docx, describe what your results mean in a descriptive language.
  11. Send Task03-Non-Compartment_Analysis.docx and Task03-Non-Compartment_Analysis.phxproj to me.

Tips and Notes

  • The path of the example is wrong in the instructions. The path should be C:\Program Files (x86)\Pharsight\Pheonix\application\Examples\

Student Data

Task #4-Bioequivalence

Click for instructions herePDF Version

  1. Make an MS Word docx document called Task04-Bioequivalence.docx
  2. On the first page describe the following abbreviations in easy to understand language:
    1. ln(AUClast), Hypothesis, Numer_DF, Denom_DF, F_Stat, P_value, CI_90_Lower, CI_90_Upper
  3. In simple language, describe what a 2x2 and a 2x4 crossover study.
  4. Open Phoenix WinNonLin
  5. Create a new project called Task04-2x2-Bioequivalence.phxproj
  6. Import dataset based on your student number such as Task04-2x2-Student01.csv.
  7. Put a copy of the Average Bioequivalence worksheet on a page of Task04-Bioequivalence.docx
    1. Label and underline with 2x2 Crossover
  8. Put the Partial Tests and Sequential Tests worksheets on a page of Task04-Bioequivalence.docx
    1. Label and underline with 2x2 Crossover
  9. Create a new project called Task04-2x4-Bioequivalence.phxproj
  10. Import dataset based on your student number such as Task04-2x4-Student01.csv
  11. Put a copy of the Average Bioequivalence worksheet on a page of Task04-Bioequivalence.docx
    1. Label and underline with 2x4 Crossover
  12. Put the Partial Tests and Sequential Tests worksheets on a page of Task04-Bioequivalence.docx
    1. Label and underline with 2x4 Crossover
  13. Put the Population Individual worksheet on a page of Task04-Bioequivalence.docx
    1. Label and underline with 2x4 Crossover
  14. In Task04-Bioequivalence.docx, describe what your 2x2 and 2x4 crossover study mean in a descriptive language.

Student Data

Information

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