Table of Drugs and Targets

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  • Original List of Drugs and Targets
Generic Name Brand Name Approval year Indication Drug Class Drug Function
Cevimeline Evoxac 2000 dry mouth Cholinergic agonist M3 muscarinic agonist
Oxcarbazepine Trileptal 2000 epilepsy Dibenzazepine unclear (Na channel inhibitor?)
Pantoprazole Protonix 2000 gastroesophageal reflux disease Proton pump inhibitor gastric acid secretion inhibitor
Alosetron Lotronex 2000 irritable bowel syndrome 5-HT3 receptor antagonist 5-HT3 antagonist
Pneumococcal 7-valent vaccine Prevnar 2000 Streptococcus pneumoniae vaccine vaccine
moroctocog alpha ReFacto 2000 hemophilia factor VIII analog co-factor of thrombin activation cascade
Zonisamide Zonegran 2000 epilepsy Sulfonamide anticonvulsant Sulfonamide anticonvulsant
Articaine, Epinephrine Septocaine 2000 anesthesia Local anesthetic Local anesthesia + vasoconstriction
Verteporfin Visudyne 2000 macular degeneration Photosensitizing agent light-activated phototherapy
Meloxicam Mobic 2000 osteoarthritis NSAID COX-1 and COX-2 inhibitor
Linezolid Zyvox 2000 Gram-positive infections Oxazolidinone antibacterial bacterial protein synthesis inhibitor
Insulin Glargine Lantus 2000 diabetes Insulin Protein replacement therapy
Rivastigmine Exelon 2000 Alzheimer's disease Acetylcholinesterase inhibitor Acetylcholinesterase inhibitor
Gemtuzumab Ozogamicin Mylotarg 2000 leukemia conjugated monoclonal antibody conjugated immunotoxin
Insulin Aspart NovoLog 2000 diabetes Insulin Protein replacement therapy
Triptorelin Trelstar Depot 2000 prostate cancer Synthetic gonadotropin-releasing hormone analog steroid secretion inhibitor
tenecteplase TNKase 2000 acute myocardial

infarction

Thrombolytic agent plasminogen converting enzyme
Argatroban Acova 2000 thrombosis Thrombin inhibitor direct thrombin inhibitor
Tinzaparin Innohep 2000 deep vein thrombosis Low molecular weight heparin antithrombin enhancer
Balsalazide Colazal 2000 inflammatory bowel disease 5-Aminosalicylic acid derivative unclear
Docosanol Abreva 2000 cold sores, fever blisters from HSV antiviral antiviral
Unoprostone Rescula 2000 glaucoma Prostaglandin analog Prostaglandin analog
Cetrorelix Cetrotide 2000 in-vitro fertilization GnRH antagonist GnRH antagonist
Lopinavir; Ritonavir Kaletra 2000 HIV Protease inhibitor HIV protease inhibitor
Arsenic Trioxide Trisenox 2000 leukemia DNA fragmentation agent unclear (DNA fragmentation agent?)
Mifepristone Mifeprex 2000 contraception Abortifacient progesterone receptor antagonist
crotalidae polyvalent immune Fab, ovine CroFab 2000 Snake Bites Venom specific immunoglobulin Fab fragment polyclonal antibody
Bivalirudin Angiomax 2000 unstable angina Thrombin inhibitor direct thrombin inhibitor
Nateglinide Starlix 2000 diabetes Meglitinide insulin secretagogue
botulinum toxin type B Myobloc 2000 cervical dystonia neurotoxin acetylcholine release inhibitor
Caspofungin Cancidas 2001 aspergillosis Echinocandin glucan synthase inhibitor
Peginterferon alfa-2b PEGIntron 2001 hepatitis C Pegylated virus proliferation inhibitor multiple intracellular signal transduction pathways activator
Ziprasidone Geodon 2001 schizophrenia Benzisoxazole derivative D2/5HT2A antagonist
Formoterol Foradil 2001 asthma β2-agonist bronchodilator
Galantamine Reminyl 2001 Alzheimer's disease Acetylcholinesterase inhibitor Acetylcholinesterase inhibitor
Travoprost Travatan 2001 glaucoma Prostaglandin analog PGF2α analog
Bimatoprost Lumigan 2001 glaucoma Prostaglandin analog PGF2α analog
Almotriptan Axert 2001 migraine 5-HT1B/1D agonist 5-HT1B/1D agonist
Imatinib Gleevec 2001 leukemia kinase inhibitor tyrosine kinase inhibitor
Drospirenone; Ethinyl Estradiol Yasmin 2001 contraception Estrogen/progestogen combination ovulation suppression
alemtuzumab Campath 2001 leukemia Monoclonal antibody/CD52-blocker ADCC
Nesiritide Natrecor 2001 congestive heart failure Human B-type natriuretic peptide smooth muscle cell relaxation
Zoledronic Acid Zometa 2001 hypercalcemia of malignancy Bisphosphonate osteoclast inhibitor
Cefditoren Spectracef 2001 Chronic Bronchitis, Pharyngitis/Tonsillitis, skin infections Cephalosporin bacterial cell wall synthesis inhibitor
darbepoetin alfa Aranesp 2001 anemia erythropoiesis-stimulating agent erythropoietin receptor activator
digoxin immune fab [ovine] DigiFab 2001 digoxin toxicity Immune Globulin digoxin sequestration
Etonogestrel; Ethinyl Estradiol Vaginal Ring NuvaRing 2001 contraception Estrogen/progestogen combination ovulation suppression
Tenofovir Viread 2001 HIV Nucleotide analogue reverse transcriptase inhibitor HIV-1 reverse transcriptase inhibitr
Frovatriptan Frova 2001 migraine 5-HT1B/1D agonist 5-HT1B/1D agonist
Valdecoxib Bextra 2001 inflammation, pain, dysmenorrhea NSAID COX-2 inhibitor
Bosentan Tracleer 2001 pulmonary arterial hypertension Endothelin antagonist vasodilatation
Dutasteride Avodart 2001 prostatic hyperplasia Type I and II 5 α-reductase inhibitor testosterone conversion enzyme inhibitor
Norelgestromin; Ethinyl Estradiol Ortho Evra 2001 contraception Estrogen/progestogen combination ovulation suppression
Ertapenem Invanz 2001 gram+ and gram- infections Carbapenem bacterial cell wall synthesis inhibitor
anakinra Kineret 2001 rheumatoid arthritis Interleukin-1 antagonist IL-1 inhibitor
drotrecogin alfa Xigris 2001 sepsis blood coagulation cascade inhibitor factors Va/VIIIa inhibitor
Fondaparinux Arixtra 2001 deep vein thrombosis Specific factor Xa inhibitor antithrombin III potentiator
Pimecrolimus Elidel 2001 atopic dermatitis Macrolactam ascomycin derivative unclear (IL-2 inhibitor?)
Desloratadine Clarinex 2001 allergic rhinitis H1-antagonist histamine release inhibitor
Nitisinone Orfadin 2002 hereditary tyrosinemia type 1 4-hydroxyphenylpyruvate dioxygenase inhibitor 4-hydroxyphenylpyruvate dioxygenase inhibitor
pegfilgrastim Neulasta 2002 neutropenia Granulocyte colony stimulating factor hematopoiesis stimulator
ibritumomab tiuxetan Zevalin 2002 lymphoma Monoclonal antibody/CD20-blocker conjugated radioimmunotherapy
interferon beta 1a Rebif 2002 multiple sclerosis Biological response modifier unclear ((IFNAR1/IFNAR2c modulator)
Fulvestrant Faslodex 2002 breast cancer Estrogen receptor antagonist Estrogen receptor antagonist
Olmesartan Benicar 2002 hypertension Angiotensin II receptor antagonist angiotensin II receptor antagonist
Treprostinil Remodulin 2002 pulmonary arterial hypertension Pulmonary and systemic vasodilator vasodilatation
Voriconazole Vfend 2002 Aspergillus and Candida infections Azole antifungal ergosterol synthesis inhibitor
Sodium Oxybate Xyrem 2002 Cataplexy CNS Depressant unclear (GHB/GABA(B) modulator?)
Tegaserod Zelnorm 2002 irritable bowel syndrome 5-HT4 agonist 5-HT4 agonist
rasburicase Elitek 2002 tumor lysis syndrome enzyme uric acid conversion enhancer
Oxaliplatin Eloxatin 2002 colorectal cancer Organoplatinum complex DNA synthesis inhibitor
Adefovir Hepsera 2002 hepatitis B Nucleotide analogue reverse transcriptase inhibitor HBV DNA polymerase inhibitor
Eplerenone Inspra 2002 chronic heart failure Aldosterone blocker Aldosterone blocker
Ezetimibe Zetia 2002 hypercholesterolemia Cholesterol absorption inhibitor Cholesterol absorption inhibitor
peginterferon alfa-2a Pegasys 2002 hepatitis C Pegylated virus proliferation inhibitor unclear ((IFNAR1/IFNAR2c modulator)
Aripiprazole Abilify 2002 schizophrenia Partial D2/5HT1A agonist/5HT2A antagonist Partial D2/5HT1A agonist and 5HT2A antagonist
Nitazoxanide Alinia 2002 giardia, cryptosporidium infections Antiprotozoal agent disruption of anaerobic energy metabolism
Atomoxetine Strattera 2002 ADHD Selective norepinephrine reuptake inhibitor Selective norepinephrine reuptake inhibitor
Teriparatide Forteo 2002 osteoporosis Recombinant human parathyroid hormone Protein replacement therapy
Icodextrin Extraneal 2002 chronic renal failure sequestering agent sequestering agent
alpha-1-antitrypsin Aralast 2002 Alpha 1-antitrypsin deficiency α1-Proteinase Inhibitor Enzyme replacement therapy
Eletriptan Relpax 2002 migraine 5-HT1B/1D agonist 5-HT1B/1D agonist
adalimumab Humira 2002 rheumatoid arthritis Monoclonal antibody/TNFα blocker TNFα blocker
alefacept Amevive 2003 psoriasis Immunosuppressive agent Immunosuppressive agent
Enfuvirtide Fuzeon 2003 HIV Fusion inhibitor entry inhibitor
Pegvisomant Somavert 2003 acromegaly GH receptor antagonist disruption of GH signal transduction
Aprepitant Emend 2003 emesis neurokinin-1 antagonist neurokinin-1 antagonist
Gemifloxacin Factive 2003 bronchitis, pneumonia Fluoroquinolone DNA synthesis inhibitor
agalsidase beta Fabrazyme 2003 Fabry's disease enzyme Enzyme replacement therapy
Laronidase Aldurazyme 2003 Mucopolysaccharidosis enzyme Enzyme replacement therapy
Gefitinib Iressa 2003 lung cancer Kinase inhibitor tyrosine kinase inhibitor
Bortezomib Velcade 2003 multiple myeloma Proteasome inhibitor proteasome inhibitor
Ibandronic acid Boniva 2003 osteoporosis Bisphosphonate osteoclast inhibitor
Alfuzosin Uroxatral 2003 prostatic hyperplasia α1-antagonist α1-antagonist
Atazanavir Reyataz 2003 HIV Protease inhibitor HIV protease inhibitor
tositumomab and tositumomab I-131 Bexxar 2003 lymphoma Monoclonal antibody/CD20-blocker conjugated radioimmunotherapy
omalizumab Xolair 2003 asthma Monoclonal antibody/IgE-blocker IgE receptor blocker
Emtricitabine Emtriva 2003 HIV Nucleoside reverse transcriptase inhibitor HIV DNA polymerase inhibitor
Alpha-1-Proteinase Inhibitor (Human) Zemaira 2003 Alpha 1-antitrypsin deficiency α1-Proteinase Inhibitor Enzyme Replacement therapy
Palonosetron Aloxi 2003 emesis 5-HT3 receptor antagonist 5-HT3 antagonist
Recombinant clotting factor VIII Advate 2003 hemophilia factor VIII analog co-factor of thrombin activation cascade
Miglustat Zavesca 2003 Gaucher's disease enzyme inhibitor Substrate reduction therapy
Rosuvastatin Crestor 2003 hypercholesterolemia HMG-CoA reductase inhibitor HMG-CoA reductase inhibitor
Vardenafil Levitra 2003 erectile dysfunction PDE5 inhibitor PDE5 inhibitor
Immune Globulin Intravenous (Human), 10% by Chromatography Process Gamunex 2003 idiopathic thrombocytopenic purpura, primary immune deficiency Immune Globulin unclear
Daptomycin Cubicin 2003 Gram-positive infections Cyclic lipopeptide bacterial DNA, RNA and protein synthesis inhibitor
Prussian Blue Radiogardase 2003 caesium-137 poisoning sequestering agent sequestering agent
Epinastine Elestat 2003 allergic conjunctivitis H1-antagonist histamine release inhibitor
Memantine Namenda 2003 Alzheimer's disease NMDA receptor antagonist NMDA receptor antagonist
Botulism Immune Globulin BabyBIG 2003 infant botulism Immune Globulin unclear
efalizumab Raptiva 2003 psoriasis Monoclonal antibody/anti-CD11a lymphocyte activation inhibitor
Tadalafil Cialis 2003 erectile dysfunction PDE5 inhibitor PDE5 inhibitor
Abarelix Plenaxis 2003 prostate cancer GnRH antagonist GnRH antagonist
Sertaconazole Ertaczo 2003 interdigital tinea pedis Azole antifungal ergosterol synthesis inhibitor
Immune Globulin Intravenous (Human) Flebogamma 2003 primary immune deficiency Immune Globulin unclear
Tiotropium Spiriva 2004 COPD Muscarinic antagonist M3 muscarinic acetylcholine antagonist
Pemetrexed Alimta 2004 mesothelioma Antifolate purine and pyrimidine synthesis inhibitor
Cetuximab Erbitux 2004 colorectal cancer Monoclonal antibody/EGFR-blocker EGFR inhibitor
Bevacizumab Avastin 2004 colorectal cancer Monoclonal antibody/VEGF blocker angiogenesis inhibitor
Cinacalcet Sensipar 2004 hyperparathyroidism, hypercalcemia Calcimimetic agent calcium-sensing receptor activator
Telithromycin Ketek 2004 bronchitis, sinusitis, pneumonia Ketolide antibiotic bacterial protein synthesis inhibitor
Insulin Glulisine Apidra 2004 diabetes Insulin Protein replacement therapy
Apomorphine Apokyn 2004 Parkinson's disease Non-ergoline dopamine agonist Non-ergoline dopamine agonist
Tinidazole Tindamax 2004 Trichomoniasis, giardiasis, amebiasis Antiprotozoal agent unclear
Azacitidine Vidaza 2004 myelodysplastic syndrome DNA methyltransferase inhibitor apoptosis
Immune Globulin Intravenous (Human) Octagam 2004 primary immune deficiency Immune Globulin unclear
Rifaximin Xifaxan 2004 travelers’ diarrhea Semisynthetic rifampin analog bacterial RNA synthesis inhibitor
Trospium Sanctura 2004 Overactive bladder Muscarinic antagonist M1 Muscarinic acetylcholine antagonist
L-Glutamine NutreStore 2004 Short

Bowel Syndrome

Dietary supplement unclear
Acamprosate Campral 2004 alcohol dependence GABA analog GABA analog
Duloxetine Cymbalta 2004 depression Serotonin and norepinephrine reuptake inhibitor Serotonin and norepinephrine reuptake inhibitor
Lanthanum Fosrenol 2004 end stage renal disease Phosphate binder phosphate sequestration
Omega-3 acids Lovaza 2004 hypertriglyceridemia Lipid-regulating agent unclear
Erlotinib Tarceva 2004 pancreatic cancer kinase inhibitor tyrosine kinase inhibitor
Solifenacin VESIcare 2004 Overactive bladder Muscarinic antagonist M3 muscarinic acetylcholine antagonist
natalizumab Tysabri 2004 multiple sclerosis Monoclonal antibody/VCAM-1 blocker α4 integrin antagonist
Palifermin Kepivance 2004 oral mucositis Keratinocyte growth factor epithelial cell proliferation
Eszopiclone Lunesta 2004 insomnia Nonbenzodiazepine hypnotic agent unclear (GABA-A agonist?)
Pegaptanib Macugen 2004 age-related macular degeneration VEGF inhibitor VEGF antagonist
Darifenacin Enablex 2004 Overactive bladder Muscarinic antagonist M3 muscarinic acetylcholine antagonist
Ziconotide Prialt 2004 pain N-type Calcium Channel Blocker N-type Calcium Channel Blocker
Clofarabine Clolar 2004 leukemia Antimetabolite DNA synthesis inhibitor
Iloprost Ventavis 2004 pulmonary arterial hypertension Prostaglandin analog vasodilatation
Pregabalin Lyrica 2004 pain associated with diabetic peripheral neuropathy GABA analog GABA analog
Pramlintide Symlin 2005 diabetes Synthetic amylin analog Protein replacement therapy
Micafungin Mycamine 2005 Candida infections Echinocandin glucan synthase inhibitor
Entecavir Baraclude 2005 hepatitis B Nucleoside reverse transcriptase inhibitor HBV DNA polymerase inhibitor
Immune Globulin Intravenous [Human] Solution Gammagard 2005 primary immune deficiency Immune Globulin unclear
Exenatide Byetta 2005 diabetes Incretin mimetic GLP-1 agonist
CNJ-016, Vaccinia Immune Globulin Intravenous (Human) VIGIV 2005 complications of vaccinia vaccination vaccine vaccine
Galsulfase Naglazyme 2005 Mucopolysaccharidosis VI Enzyme Enzyme replacement therapy
Tigecycline Tygacil 2005 broad-spectrum infections Glycylcycline bacterial protein synthesis inhibitor
Insulin Detemir Levemir 2005 diabetes insulin Protein replacement therapy
Tipranavir Aptivus 2005 HIV Protease inhibitor HIV protease inhibitor
Ramelteon Rozerem 2005 insomnia Melatonin agonist MT1 and MT2 receptor agonist
Nepafenac Nevanac 2005 pain, inflammation NSAID prostaglandin biosynthesis inhibitor
Mecasermin Recombinant Increlex 2005 growth failure in children with severe primary IGF-1 deficiency IGF-1 IGF-1 receptor activator
Nelarabine Arranon 2005 leukemia Deoxyguanosine analogue DNA synthesis inhibitor
Deferasirox Exjade 2005 hemochromatosis Iron-chelating agent iron sequestration
Mecasermin Rinfabate [rDNA Origin] Iplex 2005 growth failure in children with severe primary IGF-1 deficiency IGF-1/IGFBP-3 complex IGF-1 receptor activator
Sorafenib Nexavar 2005 renal cell carcinoma Kinase inhibitor tyrosine kinase inhibitor
Abatacept Orencia 2005 rheumatoid arthritis Selective costimulation modulator CTLA4-Ig agonist
Lenalidomide Revlimid 2005 multiple myeloma Thalidomide Analog apoptosis, anti-angiogenesis, anti-osteoclastogenesis
Conivaptan Vaprisol 2005 Hyponatremia Arginine vasopressin antagonist V1A/V2 receptor antagonist
Immune Globulin Subcutaneous (Human) Vivaglobin 2006 primary immune deficiency Immune Globulin unclear
Sunitinib Sutent 2006 renal cell carcinoma, GIST Kinase inhibitor tyrosine kinase inhibitor
Ranolazine Ranexa 2006 angina pectoris partial fatty acid oxidation inhibitors unclear (pFOX inhibitor?)
Hepatitis B Immune Globulin (Human) HepaGam B 2006 hepatitis B Immune Globulin unclear
lubiprostone Amitiza 2006 irritable bowel syndrome Chloride channel activator ClC-2 chloride channel activator
Rotavirus Vaccine, Live, Oral, Pentavalent RotaTeq 2006 rotavirus vaccine vaccine
Anidulafungin Eraxis 2006 Candida infections Echinocandin glucan synthase inhibitor
Alglucosidase alfa Myozyme 2006 Pompe disease enzyme Enzyme replacement therapy
decitabine Dacogen 2006 myelodysplastic syndrome DNA methyltransferase inhibitor apoptosis
varenicline Chantix 2006 smoking addiction Nicotinic Acetylcholine Agonist α4β2 neuronal nicotinic acetylcholine receptor agonist
rasagiline Azilect 2006 Parkinson's disease Monoamine oxidase inhibitor (Type B) MAO-B inhibitor
Zoster Vaccine, Live Zostavax 2006 shingles vaccine vaccine
Human papillomavirus vaccine Gardasil 2006 cervical cancer vaccine vaccine
darunavir Prezista 2006 HIV Protease inhibitor HIV protease inhibitor
dasatinib Sprycel 2006 leukemia Kinase inhibitor tyrosine kinase inhibitor
ranibizumab Lucentis 2006 macular degeneration Monoclonal antibody/VEGF-A blocker angiogenesis inhibitor
idursulfase Elaprase 2006 Hunter syndrome Enzyme Enzyme replacement therapy
posaconazole Noxafil 2006 Aspergillus and Candida infections Azole antifungal ergosterol synthesis inhibitor
panitumumab Vectibix 2006 colorectal cancer Monoclonal antibody/EGFR-blocker EGFR inhibitor
biskalcitrate; metronidazole; tetracycline hydrochloride Pylera 2006 Helicobacter pylori antimicrobial combination against H. Pylori unclear
vorinostat Zolinza 2006 lymphoma Histone deacetylase inhibitor histone deacetylase inhibitor
sitagliptin Januvia 2006 diabetes Dipeptidyl peptidase-4 inhibitor DPP4 inhibitor
ciclesonide Omnaris 2006 allergic rhinitis Non-halogenated glucocorticoid unclear
telbivudine Tyzeka 2006 hepatitis B Nucleoside reverse transcriptase inhibitor HBV DNA polymerase inhibitor
Sinecatechins Veregen 2006 external genital and perianal warts Sinecatechins unclear
paliperidone Invega 2006 schizophrenia Benzisoxazole derivative D2/5HT2A antagonist
lisdexamfetamine Vyvanse 2007 ADHD Sympathomimetic amine Norepinephrine-dopamine reuptake inhibitor
aliskiren Tekturna 2007 hypertension Renin inhibitor renin inhibitor
lapatinib Tykerb 2007 breast cancer Kinase inhibitor tyrosine kinase inhibitor
eculizumab Soliris 2007 paroxysmal nocturnal hemoglobinuria Monoclonal antibody/Protein C5 blocker Complement C5 inhibitor
Protein C Concentrate (Human) Ceprotin 2007 venous thrombosis, purpura fulminans Vitamin K-dependent coagulation factor inhibitor factors Va/VIIIa inhibitor
retapamulin Altabax 2007 bacterial skin infections Pleuromutilin antibacterial bacterial protein synthesis inhibitor
rotigotine Neupro 2007 Parkinson's disease Non-ergoline dopamine agonist Non-ergoline dopamine agonist
temsirolimus Torisel 2007 renal cell carcinoma mTOR inhibitor mTOR inhibitor
ambrisentan Letairis 2007 pulmonary arterial hypertension Endothelin antagonist vasodilatation
Immune Globulin Intravenous (Human), 10% Liquid Privigen 2007 Primary immunodeficiency, Chronic immune thrombocytopenic purpura Immune Globulin unclear
Maraviroc Selzentry 2007 HIV CCR5 co-receptor antagonist entry inhibitor
Thrombin, Topical (Human) Evithrom 2007 hemostasis Topical Thrombin fibrinogen activator
Lanreotide Somatuline Depot 2007 acromegaly Somatostatin analog GH inhibitor
doripenem Doribax 2007 Complicated intra-abdominal infections, Complicated urinary tract infections, including pyelonephritis Carbapenem bacterial cell wall synthesis inhibitor
raltegravir Isentress 2007 HIV HIV-integrase strand transfer inhibitor HIV-1 integrase inhibitor
ixabepilone Ixempra 2007 breast cancer Antimicrotubule agent mitotic inhibitor
nilotinib Tasigna 2007 leukemia Kinase inhibitor tyrosine kinase inhibitor
methoxy polyethylene glycol-epoetin beta Mircera 2007 anemia erythropoiesis-stimulating agent erythropoietin receptor activator
sapropterin Kuvan 2007 Phenylketonuria Synthetic tetrahydrobiopterin phenylalanine hydroxylase activator
nebivolol Bystolic 2007 hypertension Selective β1-blocker Selective β1-blocker
Etravirine Intelence 2008 HIV Non-nucleoside reverse transcriptase inhibitor Non-nucleoside reverse-transcriptase inhibitor
Rilonacept Arcalyst 2008 cryopyrin-associated periodic syndromes Interleukin-1 antagonist IL-1 inhibitor
Desvenlafaxine Pristiq 2008 depression Serotonin and norepinephrine reuptake inhibitor Serotonin and norepinephrine reuptake inhibitor
Bendamustine Treanda 2008 leukemia Alkylating agent Alkylating agent
Rotavirus vaccine Rotarix 2008 rotavirus vaccine vaccine
Certolizumab pegol Cimzia 2008 Crohn’s disease Monoclonal antibody/TNFα blocker TNFα blocker
Methylnaltrexone Relistor 2008 constipation Opioid antagonist µ-opioid antagonist
Alvimopan Entereg 2008 recovery from surgery Opioid antagonist µ-opioid antagonist
Peginterferon + Ribavirin Pegpak 2008 Hepatitis C antiviral antiviral
Difluprednate Durezol 2008 occular inflammation, pain Corticosteroid Corticosteroid
Clevidipine Cleviprex 2008 hypertension L-type Calcium channel blocker (dihydropyridine) Calcium channel blocker (dihydropyridine)
Tetrabenazine Xenazine 2008 Huntington's Disease Monoamine depletor VMAT-inhibitor
Romiplostim Nplate 2008 Idiopathic thrombocytopenic purpura Thrombopoietin receptor agonist Thrombopoietin receptor agonist
Silodosin Rapaflo 2008 benign prostatic hyperplasia α1-antagonist α1-antagonist
C1 Esterase Inhibitor (Human) Cinryze 2008 Hereditary angioedema C1 inhibitor C1 esterase inhibitor
Lacosamide Vimpat 2008 epilepsy Sodium channel inactivator unclear (Na channel inhibitor?)
Fesoterodine Toviaz 2008 Overactive bladder Muscarinic antagonist Muscarinic antagonist (multiple subtypes)
Rufinamide Banzel 2008 Lennox-Gastaut syndrome Triazole derivative unclear
Eltrombopag Promacta 2008 Thrombocytopenia Thrombopoietin receptor agonist Thrombopoietin receptor agonist
Tapentadol Nucynta 2008 pain Analgesic µ-opioid agonist; norepinephrine reuptake inhibitor
Fospropofol Lusedra 2008 general anesthesia Anesthetic agent GABA-A agonist
Plerixafor Mozobil 2008 lymphoma, myeloma Hematopoetic stem cell mobilizer CXCR4 chemokine inhibitor
Degarelix Firmagon 2008 prostate cancer GnRH antagonist GnRH antagonist
Milnacipran Savella 2009 Fibromyalgia Serotonin and norepinephrine reuptake inhibitor Serotonin and norepinephrine reuptake inhibitor
Febuxostat Uloric 2009 hyperuricemia Xanthine oxidase inhibitor Xanthine oxidase inhibitor
Everolimus Afinitor 2009 pancreatic cancer, renal cell carcinoma, Astrocytoma Kinase inhibitor mTOR inhibitor
Artemether + Lumefantrine Coartem 2009 malaria Artemisinin-based combination therapy Artemisinin-based combination therapy
Golimumab Simponi 2009 Rheumatoid arthritis, Psoriatic Arthritis, Ankylosing spondylitis Monoclonal antibody/TNFα blocker TNFα blocker
AbobotulinumtoxinA Dysport 2009 cervical dystonia neurotoxin acetylcholine release inhibitor
Iloperidone Fanapt 2009 schizophrenia Benzisoxazole derivative D2/5HT2A antagonist
Tolvaptan Samsca 2009 Hyponatremia Arginine vasopressin antagonist V2 receptor antagonist
Besifloxacin Besivance 2009 bacterial conjunctivitis Fluoroquinolone DNA synthesis inhibitor
Canakinumab Ilaris 2009 Muckle–Wells syndrome, familial cold autoinflammatory syndrome, neonatal-onset multisystem inflammatory disease Monoclonal antibody/IL-1β IL-1β inhibitor
Dronedarone Multaq 2009 cardiac arrhythmia Class III antiarrhythmic Class III antiarrhythmic
Prasugrel Effient 2009 thrombosis Platelet aggregation inhibitor Platelet aggregation inhibitor
Saxagliptin Onglyza 2009 diabetes Dipeptidyl peptidase-4 inhibitor DPP4 inhibitor
Pitavastatin Livalo 2009 hypercholesterolemia HMG-CoA reductase inhibitor HMG-CoA reductase inhibitor
Asenapine Saphris 2009 schizophrenia Dibenzazepine D2/5HT2A antagonist
Vigabatrin Sabril 2009 epilepsy GABA analog GABA analog
Bepotastine Bepreve 2009 allergic conjunctivitis H1-antagonist histamine release inhibitor
Telavancin Vibativ 2009 skin infections Lipoglycopeptide antibacterial agent bacterial cell wall synthesis inhibitor
Pralatrexate Folotyn 2009 lymphoma Dihydrofolic acid reductase inhibitor Folate analog metabolic inhibitor
Ustekinumab Stelara 2009 psoriasis Monoclonal antibody/IL-12 and IL-23 blocker IL-12 and IL-23 inhibitor
C1 Esterase Inhibitor (Human) Berinert 2009 Hereditary angioedema C1 inhibitor C1 esterase inhibitor
Human papilloma virus vaccine Cervarix 2009 cervical cancer Vaccine Vaccine
Alpha1-Proteinase Inhibitor Prolastin-C 2009 panacinar emphysema α1-Proteinase Inhibitor Enzyme Replacement therapy
Pazopanib Votrient 2009 renal cell carcinoma Kinase inhibitor tyrosine kinase inhibitor
Ofatumumab Arzerra 2009 leukemia Monoclonal antibody/CD20-blocker B lymphocyte inhibition
Romidepsin Istodax 2009 lymphoma Histone deacetylase inhibitor Histone deacetylase inhibitor
Capsaicin Qutenza 2009 Postherpetic neuralgia Analgesic TRPV1 channel agonist
Ecallantide Kalbitor 2009 hereditary angioedema Plasma kallikrein inhibitor Plasma kallikrein inhibitor
Tocilizumab Actemra 2010 Rheumatoid arthritis Monoclonal antibody/IL-6-blocker IL-6 antagonist
Dalfampridine Ampyra 2010 multiple sclerosis Potassium channel blocker Potassium channel blocker
Liraglutide Victoza 2010 diabetes Incretin mimetic GLP-1 agonist
Collagenase clostridium histolyticum Xiaflex 2010 Dupuytren's contracture Debriding/Healing Agent anti-collagen enzyme
Velaglucerase alfa Vpriv 2010 Gaucher's disease enzyme Enzyme replacement therapy
Immune Globulin (Human) Hizentra 2010 primary immune deficiency Immune Globulin unclear
Carglumic Acid Carbaglu 2010 Hyperammonemia Carbamoyl Phosphate Synthetase 1 enzyme activator
Polidocanol Asclera 2010 varicose veins Sclerosing Agent Sclerosing Agent
Sipuleucel-T Provenge 2010 prostate cancer Immunomodulator immunostimulant
Estradiol valerate + dienogest Natazia 2010 contraception Estrogen/progestogen combination ovulation suppression
Alglucosidase alfa Lumizyme 2010 Pompe disease enzyme Enzyme replacement therapy
Denosumab Prolia 2010 osteoporosis Monoclonal antibody/RANKL-blocker osteoclast inhibitor
Cabazitaxel Jevtana 2010 prostate cancer Antimicrotubule agent mitotic inhibitor
Alpha1-Proteinase Inhibitor (Human) Glassia 2010 emphysema enzyme Enzyme replacement therapy
Alcaftadine Lastacaft 2010 allergic conjunctivitis H1-antagonist histamine release inhibitor
incobotulinumtoxinA Xeomin 2010 cervical dystonia, Blepharospasm neurotoxin acetylcholine release inhibitor
Ulipristal Ella 2010 contraception Emergency contraceptive selective progesterone receptor modulator
Pegloticase Krystexxa 2010 gout Recombinant urate-oxidase enzyme uric acid conversion enhancer
Fingolimod Gilenya 2010 multiple sclerosis Sphingosine 1-phosphate receptor modulator Sphingosine 1-phosphate modulator
Dabigatran Pradaxa 2010 stroke Thrombin inhibitor direct thrombin inhibitor
Lurasidone Latuda 2010 schizophrenia Benzoisothiazol derivative D2/5HT2A antagonist
Ceftaroline Teflaro 2010 broad-spectrum infections Cephalosporin bacterial cell wall synthesis inhibitor
Tesamorelin Egrifta 2010 lipodystrophy Growth hormone-releasing factor growth hormone release-stimulating peptide
Eribulin Halaven 2010 breast cancer Antimicrotubule agent mitotic inhibitor
Spinosad Natroba 2011 head lice Pediculocide nicotinic acetylcholine receptor activator
Vilazodone Viibryd 2011 depression SSRI 5-HT1A partial agonist
Factor XIII Corifact 2011 Factor XIII deficiency Plasma glycoprotein fibrin cross-linker
Azilsartan Edarbi 2011 hypertension Angiotensin II receptor antagonist angiotensin II receptor antagonist
Roflumilast Daliresp 2011 COPD PDE4 inhibitor PDE4 inhibitor
Belimumab Benlysta 2011 lupus Monoclonal antibody/BLyS blocker BLyS blocker
Ipilimumab Yervoy 2011 melanoma Monoclonal antibody/CTLA-4 blocker T-cell activation through CTLA-4 blockade
Vandetanib Caprelsa 2011 thyroid cancer Kinase inhibitor tyrosine kinase inhibitor
Gabapentin enacarbil Horizant 2011 Restless Legs Syndrome GABA analog GABA analog
Abiraterone Zytiga 2011 prostate cancer Nonsteroidal antiandrogen CYP17A1 inhibitor
Linagliptin Tradjenta 2011 diabetes Dipeptidyl peptidase-4 inhibitor DPP4 inhibitor
Boceprevir Victrelis 2011 hepatitis C Protease inhibitor NS3/4A protease inhibitor
Rilpivirine Edurant 2011 HIV Non-nucleoside reverse transcriptase inhibitor Non-nucleoside reverse-transcriptase inhibitor
Telaprevir Incivek 2011 hepatitis C Protease inhibitor NS3/4A protease inhibitor
Fidaxomicin Dificid 2011 C. difficile Macrolide RNA polymerase inhibitor
Ezogabine Potiga 2011 epilepsy Potassium channel opener Potassium channel opener
Belatacept Nulojix 2011 Graft Rejection Selective costimulation modulator CTLA4-Ig agonist
Azficel-T LaViv 2011 Smoothing nasolabial fold wrinkles in adults Autologous dermal fibroblasts unclear
Indacaterol Arcapta 2011 COPD β2-agonist bronchodilator
Rivaroxaban Xarelto 2011 deep vein thrombosis Specific factor Xa inhibitor Specific factor Xa inhibitor
Ticagrelor Brilinta 2011 acute coronary syndrome (prevention of thrombotic events) Platelet aggregation inhibitor P2Y12 platelet inhibitor
Vemurafenib Zelboraf 2011 melanoma Kinase inhibitor tyrosine kinase inhibitor
Centruroides (Scorpion) Immune F(ab')2 (Equine) Injection Anascorp 2011 scorpion envenomation antivenom immunoglobulin G
Brentuximab Vedotin Adcetris 2011 lymphoma conjugated monoclonal antibody conjugated immunotoxin
Icatibant Firazyr 2011 hereditary angioedema Bradykinin B2 antagonist Bradykinin B2 antagonist
Crizotinib Xalkori 2011 lung cancer Kinase inhibitor tyrosine kinase inhibitor
Deferiprone Ferriprox 2011 thalassemia Iron-chelating agent iron sequestration
Clobazam Onfi 2011 Lennox-Gastaut syndrome Benzodiazepine GABA-A agonist
Ruxolitinib Jakafi 2011 Myelofibrosis Kinase inhibitor Janus kinase inhibitor
Asparaginase Erwinia chrysanthemi Erwinaze 2011 acute lymphoblastic leukemia enzyme asparagine converting enzyme
Aflibercept Eylea 2011 macular degeneration VEGF inhibitor VEGF-A and PlGF inhibitor
Glucarpidase Voraxaze 2012 methotrexate toxicity enzyme methotrexate inactivation
Ingenol Picato 2012 actinic keratosis. unclear unclear
Axitinib Inlyta 2012 renal cell carcinoma Kinase inhibitor tyrosine kinase inhibitor
Vismodegib Erivedge 2012 basal cell carcinoma Hedgehog pathway inhibitor SMO inhibitor
Ivacaftor Kalydeco 2012 cistic fibrosis CFTR potentiator CFTR potentiator
Tafluprost Zioptan 2012 glaucoma prostaglandin analog prostaglandin analog
Lucinactant Surfaxin 2012 respiratory distress syndrome pulmonary surfactant pulmonary surfactant
Peginesatide Omontys 2012 anemia due to chronic kidney disease erythropoiesis-stimulating agent erythropoietin receptor activator
Avanafil Stendra 2012 erectile dysfunction PDE5 inhibitor PDE5 inhibitor
Taliglucerase alpha Elelyso 2012 Gaucher disease enzyme Enzyme replacement therapy
Pertuzumab Perjeta 2012 breast cancer Monoclonal antibody/HER2-blocker HER2/neu receptor antagonist
Lorcaserin Belviq 2012 obesity 5-HT 2C agonist 5-HT2C receptor agonist
Mirabegron Myrbetriq 2012 Overactive bladder Adrenergic/anticholinergic agent β3 adrenergic agonist
Sodium picosulfate, magnesium oxyde, citric acid Prepopik 2012 colon cleansing and preparation Bowel cleanser peristalsis stimulator
Carfilzomib Kyprolis 2012 multiple myeloma Proteasome inhibitor Proteasome inhibitor
Aclidinium Tudorza Pressair 2012 COPD Anticholinergic bronchodilator M3 muscarinic acetylcholine antagonist
Icosapent Vascepa 2012 hypertriglyceridemia Lipid-regulating agent unclear
Ziv-aflibercept Zaltrap 2012 colorectal cancer VEGF inhibitor VEGF-A inhibitor; VEGF-B inhibitor; PIGF inhibitor
Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Stribild 2012 HIV HIV integrase strand transfer inhibitor/nucleoside analogue combination mixture of 4 known MoAs
Linaclotide Linzess 2012 IBS; constipation Guanylate cyclase-C agonist Guanylate cyclase-C agonist
Enzalutamide Xtandi 2012 prostate cancer Nonsteroidal antiandrogen androgen receptor inhibitor
Bosutinib Bosulif 2012 leukemia Kinase inhibitor tyrosine kinase inhibitor
Teriflunomide Aubagio 2012 multiple sclerosis Pyrimidine synthesis inhibitor dihydroorotate dehydrogenase inhibitor
Regorafenib Stivarga 2012 colorectal cancer Kinase inhibitor tyrosine kinase inhibitor
ocriplasmin Jetrea 2012 Vitreomacular Adhesion protease proteolysis
Perampanel Fycompa 2012 epilepsy AMPA receptor antagonist AMPA receptor antagonist
Omacetaxine Synribo 2012 leukemia protein synthesis inhibitor protein synthesis inhibitor
Tofacitinib Xeljanz 2012 rheumatoid arthritis Kinase inhibitor Janus kinase inhibitor
Cabozantinib Cometriq 2012 thyroid cancer Kinase inhibitor tyrosine kinase inhibitor
Ponatinib Iclusig 2012 leukemia Kinase inhibitor tyrosine kinase inhibitor
Raxibacumab Raxibacumab 2012 anthrax Monoclonal antibody/PA antigen-blocker B Anthracis' Protective antigen antagonist
Pasireotide Signifor 2012 Cushing’s disease somatostatin analog somatostatin receptor 5 agonist
Teduglutide Gattex 2012 Short Bowel Syndrome GLP-2 analog GLP-2 analog
Lomitapide Juxtapid 2012 Homozygous familial hypercholesterolemia MTP inhibitor microsomal triglyceride transfer protein (MTP) inhibitor
Apixaban Eliquis 2012 Stroke Specific factor Xa inhibitor Specific factor Xa inhibitor
Bedaquiline Sirturo 2012 Tuberculosis diarylquinoline ATP synthase inhibitor
Crofelemer Fulyzaq 2012 Diarrhea CFTR and CaCC inhibitor CFTR and CaCC inhibitor