Table of Drugs and Targets

• Original List of Drugs and Targets

Generic Name	Brand Name	Approval year	Indication	Drug Class	Drug Function
Cevimeline	Evoxac	2000	dry mouth	Cholinergic agonist	M3 muscarinic agonist
Oxcarbazepine	Trileptal	2000	epilepsy	Dibenzazepine	unclear (Na channel inhibitor?)
Pantoprazole	Protonix	2000	gastroesophageal reflux disease	Proton pump inhibitor	gastric acid secretion inhibitor
Alosetron	Lotronex	2000	irritable bowel syndrome	5-HT3 receptor antagonist	5-HT3 antagonist
Pneumococcal 7-valent vaccine	Prevnar	2000	Streptococcus pneumoniae	vaccine	vaccine
moroctocog alpha	ReFacto	2000	hemophilia	factor VIII analog	co-factor of thrombin activation cascade
Zonisamide	Zonegran	2000	epilepsy	Sulfonamide anticonvulsant	Sulfonamide anticonvulsant
Articaine, Epinephrine	Septocaine	2000	anesthesia	Local anesthetic	Local anesthesia + vasoconstriction
Verteporfin	Visudyne	2000	macular degeneration	Photosensitizing agent	light-activated phototherapy
Meloxicam	Mobic	2000	osteoarthritis	NSAID	COX-1 and COX-2 inhibitor
Linezolid	Zyvox	2000	Gram-positive infections	Oxazolidinone antibacterial	bacterial protein synthesis inhibitor
Insulin Glargine	Lantus	2000	diabetes	Insulin	Protein replacement therapy
Rivastigmine	Exelon	2000	Alzheimer's disease	Acetylcholinesterase inhibitor	Acetylcholinesterase inhibitor
Gemtuzumab Ozogamicin	Mylotarg	2000	leukemia	conjugated monoclonal antibody	conjugated immunotoxin
Insulin Aspart	NovoLog	2000	diabetes	Insulin	Protein replacement therapy
Triptorelin	Trelstar Depot	2000	prostate cancer	Synthetic gonadotropin-releasing hormone analog	steroid secretion inhibitor
tenecteplase	TNKase	2000	acute myocardial infarction	Thrombolytic agent	plasminogen converting enzyme
Argatroban	Acova	2000	thrombosis	Thrombin inhibitor	direct thrombin inhibitor
Tinzaparin	Innohep	2000	deep vein thrombosis	Low molecular weight heparin	antithrombin enhancer
Balsalazide	Colazal	2000	inflammatory bowel disease	5-Aminosalicylic acid derivative	unclear
Docosanol	Abreva	2000	cold sores, fever blisters from HSV	antiviral	antiviral
Unoprostone	Rescula	2000	glaucoma	Prostaglandin analog	Prostaglandin analog
Cetrorelix	Cetrotide	2000	in-vitro fertilization	GnRH antagonist	GnRH antagonist
Lopinavir; Ritonavir	Kaletra	2000	HIV	Protease inhibitor	HIV protease inhibitor
Arsenic Trioxide	Trisenox	2000	leukemia	DNA fragmentation agent	unclear (DNA fragmentation agent?)
Mifepristone	Mifeprex	2000	contraception	Abortifacient	progesterone receptor antagonist
crotalidae polyvalent immune Fab, ovine	CroFab	2000	Snake Bites	Venom specific immunoglobulin Fab fragment	polyclonal antibody
Bivalirudin	Angiomax	2000	unstable angina	Thrombin inhibitor	direct thrombin inhibitor
Nateglinide	Starlix	2000	diabetes	Meglitinide	insulin secretagogue
botulinum toxin type B	Myobloc	2000	cervical dystonia	neurotoxin	acetylcholine release inhibitor
Caspofungin	Cancidas	2001	aspergillosis	Echinocandin	glucan synthase inhibitor
Peginterferon alfa-2b	PEGIntron	2001	hepatitis C	Pegylated virus proliferation inhibitor	multiple intracellular signal transduction pathways activator
Ziprasidone	Geodon	2001	schizophrenia	Benzisoxazole derivative	D2/5HT2A antagonist
Formoterol	Foradil	2001	asthma	β2-agonist	bronchodilator
Galantamine	Reminyl	2001	Alzheimer's disease	Acetylcholinesterase inhibitor	Acetylcholinesterase inhibitor
Travoprost	Travatan	2001	glaucoma	Prostaglandin analog	PGF2α analog
Bimatoprost	Lumigan	2001	glaucoma	Prostaglandin analog	PGF2α analog
Almotriptan	Axert	2001	migraine	5-HT1B/1D agonist	5-HT1B/1D agonist
Imatinib	Gleevec	2001	leukemia	kinase inhibitor	tyrosine kinase inhibitor
Drospirenone; Ethinyl Estradiol	Yasmin	2001	contraception	Estrogen/progestogen combination	ovulation suppression
alemtuzumab	Campath	2001	leukemia	Monoclonal antibody/CD52-blocker	ADCC
Nesiritide	Natrecor	2001	congestive heart failure	Human B-type natriuretic peptide	smooth muscle cell relaxation
Zoledronic Acid	Zometa	2001	hypercalcemia of malignancy	Bisphosphonate	osteoclast inhibitor
Cefditoren	Spectracef	2001	Chronic Bronchitis, Pharyngitis/Tonsillitis, skin infections	Cephalosporin	bacterial cell wall synthesis inhibitor
darbepoetin alfa	Aranesp	2001	anemia	erythropoiesis-stimulating agent	erythropoietin receptor activator
digoxin immune fab [ovine]	DigiFab	2001	digoxin toxicity	Immune Globulin	digoxin sequestration
Etonogestrel; Ethinyl Estradiol Vaginal Ring	NuvaRing	2001	contraception	Estrogen/progestogen combination	ovulation suppression
Tenofovir	Viread	2001	HIV	Nucleotide analogue reverse transcriptase inhibitor	HIV-1 reverse transcriptase inhibitr
Frovatriptan	Frova	2001	migraine	5-HT1B/1D agonist	5-HT1B/1D agonist
Valdecoxib	Bextra	2001	inflammation, pain, dysmenorrhea	NSAID	COX-2 inhibitor
Bosentan	Tracleer	2001	pulmonary arterial hypertension	Endothelin antagonist	vasodilatation
Dutasteride	Avodart	2001	prostatic hyperplasia	Type I and II 5 α-reductase inhibitor	testosterone conversion enzyme inhibitor
Norelgestromin; Ethinyl Estradiol	Ortho Evra	2001	contraception	Estrogen/progestogen combination	ovulation suppression
Ertapenem	Invanz	2001	gram+ and gram- infections	Carbapenem	bacterial cell wall synthesis inhibitor
anakinra	Kineret	2001	rheumatoid arthritis	Interleukin-1 antagonist	IL-1 inhibitor
drotrecogin alfa	Xigris	2001	sepsis	blood coagulation cascade inhibitor	factors Va/VIIIa inhibitor
Fondaparinux	Arixtra	2001	deep vein thrombosis	Specific factor Xa inhibitor	antithrombin III potentiator
Pimecrolimus	Elidel	2001	atopic dermatitis	Macrolactam ascomycin derivative	unclear (IL-2 inhibitor?)
Desloratadine	Clarinex	2001	allergic rhinitis	H1-antagonist	histamine release inhibitor
Nitisinone	Orfadin	2002	hereditary tyrosinemia type 1	4-hydroxyphenylpyruvate dioxygenase inhibitor	4-hydroxyphenylpyruvate dioxygenase inhibitor
pegfilgrastim	Neulasta	2002	neutropenia	Granulocyte colony stimulating factor	hematopoiesis stimulator
ibritumomab tiuxetan	Zevalin	2002	lymphoma	Monoclonal antibody/CD20-blocker	conjugated radioimmunotherapy
interferon beta 1a	Rebif	2002	multiple sclerosis	Biological response modifier	unclear ((IFNAR1/IFNAR2c modulator)
Fulvestrant	Faslodex	2002	breast cancer	Estrogen receptor antagonist	Estrogen receptor antagonist
Olmesartan	Benicar	2002	hypertension	Angiotensin II receptor antagonist	angiotensin II receptor antagonist
Treprostinil	Remodulin	2002	pulmonary arterial hypertension	Pulmonary and systemic vasodilator	vasodilatation
Voriconazole	Vfend	2002	Aspergillus and Candida infections	Azole antifungal	ergosterol synthesis inhibitor
Sodium Oxybate	Xyrem	2002	Cataplexy	CNS Depressant	unclear (GHB/GABA(B) modulator?)
Tegaserod	Zelnorm	2002	irritable bowel syndrome	5-HT4 agonist	5-HT4 agonist
rasburicase	Elitek	2002	tumor lysis syndrome	enzyme	uric acid conversion enhancer
Oxaliplatin	Eloxatin	2002	colorectal cancer	Organoplatinum complex	DNA synthesis inhibitor
Adefovir	Hepsera	2002	hepatitis B	Nucleotide analogue reverse transcriptase inhibitor	HBV DNA polymerase inhibitor
Eplerenone	Inspra	2002	chronic heart failure	Aldosterone blocker	Aldosterone blocker
Ezetimibe	Zetia	2002	hypercholesterolemia	Cholesterol absorption inhibitor	Cholesterol absorption inhibitor
peginterferon alfa-2a	Pegasys	2002	hepatitis C	Pegylated virus proliferation inhibitor	unclear ((IFNAR1/IFNAR2c modulator)
Aripiprazole	Abilify	2002	schizophrenia	Partial D2/5HT1A agonist/5HT2A antagonist	Partial D2/5HT1A agonist and 5HT2A antagonist
Nitazoxanide	Alinia	2002	giardia, cryptosporidium infections	Antiprotozoal agent	disruption of anaerobic energy metabolism
Atomoxetine	Strattera	2002	ADHD	Selective norepinephrine reuptake inhibitor	Selective norepinephrine reuptake inhibitor
Teriparatide	Forteo	2002	osteoporosis	Recombinant human parathyroid hormone	Protein replacement therapy
Icodextrin	Extraneal	2002	chronic renal failure	sequestering agent	sequestering agent
alpha-1-antitrypsin	Aralast	2002	Alpha 1-antitrypsin deficiency	α1-Proteinase Inhibitor	Enzyme replacement therapy
Eletriptan	Relpax	2002	migraine	5-HT1B/1D agonist	5-HT1B/1D agonist
adalimumab	Humira	2002	rheumatoid arthritis	Monoclonal antibody/TNFα blocker	TNFα blocker
alefacept	Amevive	2003	psoriasis	Immunosuppressive agent	Immunosuppressive agent
Enfuvirtide	Fuzeon	2003	HIV	Fusion inhibitor	entry inhibitor
Pegvisomant	Somavert	2003	acromegaly	GH receptor antagonist	disruption of GH signal transduction
Aprepitant	Emend	2003	emesis	neurokinin-1 antagonist	neurokinin-1 antagonist
Gemifloxacin	Factive	2003	bronchitis, pneumonia	Fluoroquinolone	DNA synthesis inhibitor
agalsidase beta	Fabrazyme	2003	Fabry's disease	enzyme	Enzyme replacement therapy
Laronidase	Aldurazyme	2003	Mucopolysaccharidosis	enzyme	Enzyme replacement therapy
Gefitinib	Iressa	2003	lung cancer	Kinase inhibitor	tyrosine kinase inhibitor
Bortezomib	Velcade	2003	multiple myeloma	Proteasome inhibitor	proteasome inhibitor
Ibandronic acid	Boniva	2003	osteoporosis	Bisphosphonate	osteoclast inhibitor
Alfuzosin	Uroxatral	2003	prostatic hyperplasia	α1-antagonist	α1-antagonist
Atazanavir	Reyataz	2003	HIV	Protease inhibitor	HIV protease inhibitor
tositumomab and tositumomab I-131	Bexxar	2003	lymphoma	Monoclonal antibody/CD20-blocker	conjugated radioimmunotherapy
omalizumab	Xolair	2003	asthma	Monoclonal antibody/IgE-blocker	IgE receptor blocker
Emtricitabine	Emtriva	2003	HIV	Nucleoside reverse transcriptase inhibitor	HIV DNA polymerase inhibitor
Alpha-1-Proteinase Inhibitor (Human)	Zemaira	2003	Alpha 1-antitrypsin deficiency	α1-Proteinase Inhibitor	Enzyme Replacement therapy
Palonosetron	Aloxi	2003	emesis	5-HT3 receptor antagonist	5-HT3 antagonist
Recombinant clotting factor VIII	Advate	2003	hemophilia	factor VIII analog	co-factor of thrombin activation cascade
Miglustat	Zavesca	2003	Gaucher's disease	enzyme inhibitor	Substrate reduction therapy
Rosuvastatin	Crestor	2003	hypercholesterolemia	HMG-CoA reductase inhibitor	HMG-CoA reductase inhibitor
Vardenafil	Levitra	2003	erectile dysfunction	PDE5 inhibitor	PDE5 inhibitor
Immune Globulin Intravenous (Human), 10% by Chromatography Process	Gamunex	2003	idiopathic thrombocytopenic purpura, primary immune deficiency	Immune Globulin	unclear
Daptomycin	Cubicin	2003	Gram-positive infections	Cyclic lipopeptide	bacterial DNA, RNA and protein synthesis inhibitor
Prussian Blue	Radiogardase	2003	caesium-137 poisoning	sequestering agent	sequestering agent
Epinastine	Elestat	2003	allergic conjunctivitis	H1-antagonist	histamine release inhibitor
Memantine	Namenda	2003	Alzheimer's disease	NMDA receptor antagonist	NMDA receptor antagonist
Botulism Immune Globulin	BabyBIG	2003	infant botulism	Immune Globulin	unclear
efalizumab	Raptiva	2003	psoriasis	Monoclonal antibody/anti-CD11a	lymphocyte activation inhibitor
Tadalafil	Cialis	2003	erectile dysfunction	PDE5 inhibitor	PDE5 inhibitor
Abarelix	Plenaxis	2003	prostate cancer	GnRH antagonist	GnRH antagonist
Sertaconazole	Ertaczo	2003	interdigital tinea pedis	Azole antifungal	ergosterol synthesis inhibitor
Immune Globulin Intravenous (Human)	Flebogamma	2003	primary immune deficiency	Immune Globulin	unclear
Tiotropium	Spiriva	2004	COPD	Muscarinic antagonist	M3 muscarinic acetylcholine antagonist
Pemetrexed	Alimta	2004	mesothelioma	Antifolate	purine and pyrimidine synthesis inhibitor
Cetuximab	Erbitux	2004	colorectal cancer	Monoclonal antibody/EGFR-blocker	EGFR inhibitor
Bevacizumab	Avastin	2004	colorectal cancer	Monoclonal antibody/VEGF blocker	angiogenesis inhibitor
Cinacalcet	Sensipar	2004	hyperparathyroidism, hypercalcemia	Calcimimetic agent	calcium-sensing receptor activator
Telithromycin	Ketek	2004	bronchitis, sinusitis, pneumonia	Ketolide antibiotic	bacterial protein synthesis inhibitor
Insulin Glulisine	Apidra	2004	diabetes	Insulin	Protein replacement therapy
Apomorphine	Apokyn	2004	Parkinson's disease	Non-ergoline dopamine agonist	Non-ergoline dopamine agonist
Tinidazole	Tindamax	2004	Trichomoniasis, giardiasis, amebiasis	Antiprotozoal agent	unclear
Azacitidine	Vidaza	2004	myelodysplastic syndrome	DNA methyltransferase inhibitor	apoptosis
Immune Globulin Intravenous (Human)	Octagam	2004	primary immune deficiency	Immune Globulin	unclear
Rifaximin	Xifaxan	2004	travelers’ diarrhea	Semisynthetic rifampin analog	bacterial RNA synthesis inhibitor
Trospium	Sanctura	2004	Overactive bladder	Muscarinic antagonist	M1 Muscarinic acetylcholine antagonist
L-Glutamine	NutreStore	2004	Short Bowel Syndrome	Dietary supplement	unclear
Acamprosate	Campral	2004	alcohol dependence	GABA analog	GABA analog
Duloxetine	Cymbalta	2004	depression	Serotonin and norepinephrine reuptake inhibitor	Serotonin and norepinephrine reuptake inhibitor
Lanthanum	Fosrenol	2004	end stage renal disease	Phosphate binder	phosphate sequestration
Omega-3 acids	Lovaza	2004	hypertriglyceridemia	Lipid-regulating agent	unclear
Erlotinib	Tarceva	2004	pancreatic cancer	kinase inhibitor	tyrosine kinase inhibitor
Solifenacin	VESIcare	2004	Overactive bladder	Muscarinic antagonist	M3 muscarinic acetylcholine antagonist
natalizumab	Tysabri	2004	multiple sclerosis	Monoclonal antibody/VCAM-1 blocker	α4 integrin antagonist
Palifermin	Kepivance	2004	oral mucositis	Keratinocyte growth factor	epithelial cell proliferation
Eszopiclone	Lunesta	2004	insomnia	Nonbenzodiazepine hypnotic agent	unclear (GABA-A agonist?)
Pegaptanib	Macugen	2004	age-related macular degeneration	VEGF inhibitor	VEGF antagonist
Darifenacin	Enablex	2004	Overactive bladder	Muscarinic antagonist	M3 muscarinic acetylcholine antagonist
Ziconotide	Prialt	2004	pain	N-type Calcium Channel Blocker	N-type Calcium Channel Blocker
Clofarabine	Clolar	2004	leukemia	Antimetabolite	DNA synthesis inhibitor
Iloprost	Ventavis	2004	pulmonary arterial hypertension	Prostaglandin analog	vasodilatation
Pregabalin	Lyrica	2004	pain associated with diabetic peripheral neuropathy	GABA analog	GABA analog
Pramlintide	Symlin	2005	diabetes	Synthetic amylin analog	Protein replacement therapy
Micafungin	Mycamine	2005	Candida infections	Echinocandin	glucan synthase inhibitor
Entecavir	Baraclude	2005	hepatitis B	Nucleoside reverse transcriptase inhibitor	HBV DNA polymerase inhibitor
Immune Globulin Intravenous [Human] Solution	Gammagard	2005	primary immune deficiency	Immune Globulin	unclear
Exenatide	Byetta	2005	diabetes	Incretin mimetic	GLP-1 agonist
CNJ-016, Vaccinia Immune Globulin Intravenous (Human)	VIGIV	2005	complications of vaccinia vaccination	vaccine	vaccine
Galsulfase	Naglazyme	2005	Mucopolysaccharidosis VI	Enzyme	Enzyme replacement therapy
Tigecycline	Tygacil	2005	broad-spectrum infections	Glycylcycline	bacterial protein synthesis inhibitor
Insulin Detemir	Levemir	2005	diabetes	insulin	Protein replacement therapy
Tipranavir	Aptivus	2005	HIV	Protease inhibitor	HIV protease inhibitor
Ramelteon	Rozerem	2005	insomnia	Melatonin agonist	MT1 and MT2 receptor agonist
Nepafenac	Nevanac	2005	pain, inflammation	NSAID	prostaglandin biosynthesis inhibitor
Mecasermin Recombinant	Increlex	2005	growth failure in children with severe primary IGF-1 deficiency	IGF-1	IGF-1 receptor activator
Nelarabine	Arranon	2005	leukemia	Deoxyguanosine analogue	DNA synthesis inhibitor
Deferasirox	Exjade	2005	hemochromatosis	Iron-chelating agent	iron sequestration
Mecasermin Rinfabate [rDNA Origin]	Iplex	2005	growth failure in children with severe primary IGF-1 deficiency	IGF-1/IGFBP-3 complex	IGF-1 receptor activator
Sorafenib	Nexavar	2005	renal cell carcinoma	Kinase inhibitor	tyrosine kinase inhibitor
Abatacept	Orencia	2005	rheumatoid arthritis	Selective costimulation modulator	CTLA4-Ig agonist
Lenalidomide	Revlimid	2005	multiple myeloma	Thalidomide Analog	apoptosis, anti-angiogenesis, anti-osteoclastogenesis
Conivaptan	Vaprisol	2005	Hyponatremia	Arginine vasopressin antagonist	V1A/V2 receptor antagonist
Immune Globulin Subcutaneous (Human)	Vivaglobin	2006	primary immune deficiency	Immune Globulin	unclear
Sunitinib	Sutent	2006	renal cell carcinoma, GIST	Kinase inhibitor	tyrosine kinase inhibitor
Ranolazine	Ranexa	2006	angina pectoris	partial fatty acid oxidation inhibitors	unclear (pFOX inhibitor?)
Hepatitis B Immune Globulin (Human)	HepaGam B	2006	hepatitis B	Immune Globulin	unclear
lubiprostone	Amitiza	2006	irritable bowel syndrome	Chloride channel activator	ClC-2 chloride channel activator
Rotavirus Vaccine, Live, Oral, Pentavalent	RotaTeq	2006	rotavirus	vaccine	vaccine
Anidulafungin	Eraxis	2006	Candida infections	Echinocandin	glucan synthase inhibitor
Alglucosidase alfa	Myozyme	2006	Pompe disease	enzyme	Enzyme replacement therapy
decitabine	Dacogen	2006	myelodysplastic syndrome	DNA methyltransferase inhibitor	apoptosis
varenicline	Chantix	2006	smoking addiction	Nicotinic Acetylcholine Agonist	α4β2 neuronal nicotinic acetylcholine receptor agonist
rasagiline	Azilect	2006	Parkinson's disease	Monoamine oxidase inhibitor (Type B)	MAO-B inhibitor
Zoster Vaccine, Live	Zostavax	2006	shingles	vaccine	vaccine
Human papillomavirus vaccine	Gardasil	2006	cervical cancer	vaccine	vaccine
darunavir	Prezista	2006	HIV	Protease inhibitor	HIV protease inhibitor
dasatinib	Sprycel	2006	leukemia	Kinase inhibitor	tyrosine kinase inhibitor
ranibizumab	Lucentis	2006	macular degeneration	Monoclonal antibody/VEGF-A blocker	angiogenesis inhibitor
idursulfase	Elaprase	2006	Hunter syndrome	Enzyme	Enzyme replacement therapy
posaconazole	Noxafil	2006	Aspergillus and Candida infections	Azole antifungal	ergosterol synthesis inhibitor
panitumumab	Vectibix	2006	colorectal cancer	Monoclonal antibody/EGFR-blocker	EGFR inhibitor
biskalcitrate; metronidazole; tetracycline hydrochloride	Pylera	2006	Helicobacter pylori	antimicrobial combination against H. Pylori	unclear
vorinostat	Zolinza	2006	lymphoma	Histone deacetylase inhibitor	histone deacetylase inhibitor
sitagliptin	Januvia	2006	diabetes	Dipeptidyl peptidase-4 inhibitor	DPP4 inhibitor
ciclesonide	Omnaris	2006	allergic rhinitis	Non-halogenated glucocorticoid	unclear
telbivudine	Tyzeka	2006	hepatitis B	Nucleoside reverse transcriptase inhibitor	HBV DNA polymerase inhibitor
Sinecatechins	Veregen	2006	external genital and perianal warts	Sinecatechins	unclear
paliperidone	Invega	2006	schizophrenia	Benzisoxazole derivative	D2/5HT2A antagonist
lisdexamfetamine	Vyvanse	2007	ADHD	Sympathomimetic amine	Norepinephrine-dopamine reuptake inhibitor
aliskiren	Tekturna	2007	hypertension	Renin inhibitor	renin inhibitor
lapatinib	Tykerb	2007	breast cancer	Kinase inhibitor	tyrosine kinase inhibitor
eculizumab	Soliris	2007	paroxysmal nocturnal hemoglobinuria	Monoclonal antibody/Protein C5 blocker	Complement C5 inhibitor
Protein C Concentrate (Human)	Ceprotin	2007	venous thrombosis, purpura fulminans	Vitamin K-dependent coagulation factor inhibitor	factors Va/VIIIa inhibitor
retapamulin	Altabax	2007	bacterial skin infections	Pleuromutilin antibacterial	bacterial protein synthesis inhibitor
rotigotine	Neupro	2007	Parkinson's disease	Non-ergoline dopamine agonist	Non-ergoline dopamine agonist
temsirolimus	Torisel	2007	renal cell carcinoma	mTOR inhibitor	mTOR inhibitor
ambrisentan	Letairis	2007	pulmonary arterial hypertension	Endothelin antagonist	vasodilatation
Immune Globulin Intravenous (Human), 10% Liquid	Privigen	2007	Primary immunodeficiency, Chronic immune thrombocytopenic purpura	Immune Globulin	unclear
Maraviroc	Selzentry	2007	HIV	CCR5 co-receptor antagonist	entry inhibitor
Thrombin, Topical (Human)	Evithrom	2007	hemostasis	Topical Thrombin	fibrinogen activator
Lanreotide	Somatuline Depot	2007	acromegaly	Somatostatin analog	GH inhibitor
doripenem	Doribax	2007	Complicated intra-abdominal infections, Complicated urinary tract infections, including pyelonephritis	Carbapenem	bacterial cell wall synthesis inhibitor
raltegravir	Isentress	2007	HIV	HIV-integrase strand transfer inhibitor	HIV-1 integrase inhibitor
ixabepilone	Ixempra	2007	breast cancer	Antimicrotubule agent	mitotic inhibitor
nilotinib	Tasigna	2007	leukemia	Kinase inhibitor	tyrosine kinase inhibitor
methoxy polyethylene glycol-epoetin beta	Mircera	2007	anemia	erythropoiesis-stimulating agent	erythropoietin receptor activator
sapropterin	Kuvan	2007	Phenylketonuria	Synthetic tetrahydrobiopterin	phenylalanine hydroxylase activator
nebivolol	Bystolic	2007	hypertension	Selective β1-blocker	Selective β1-blocker
Etravirine	Intelence	2008	HIV	Non-nucleoside reverse transcriptase inhibitor	Non-nucleoside reverse-transcriptase inhibitor
Rilonacept	Arcalyst	2008	cryopyrin-associated periodic syndromes	Interleukin-1 antagonist	IL-1 inhibitor
Desvenlafaxine	Pristiq	2008	depression	Serotonin and norepinephrine reuptake inhibitor	Serotonin and norepinephrine reuptake inhibitor
Bendamustine	Treanda	2008	leukemia	Alkylating agent	Alkylating agent
Rotavirus vaccine	Rotarix	2008	rotavirus	vaccine	vaccine
Certolizumab pegol	Cimzia	2008	Crohn’s disease	Monoclonal antibody/TNFα blocker	TNFα blocker
Methylnaltrexone	Relistor	2008	constipation	Opioid antagonist	µ-opioid antagonist
Alvimopan	Entereg	2008	recovery from surgery	Opioid antagonist	µ-opioid antagonist
Peginterferon + Ribavirin	Pegpak	2008	Hepatitis C	antiviral	antiviral
Difluprednate	Durezol	2008	occular inflammation, pain	Corticosteroid	Corticosteroid
Clevidipine	Cleviprex	2008	hypertension	L-type Calcium channel blocker (dihydropyridine)	Calcium channel blocker (dihydropyridine)
Tetrabenazine	Xenazine	2008	Huntington's Disease	Monoamine depletor	VMAT-inhibitor
Romiplostim	Nplate	2008	Idiopathic thrombocytopenic purpura	Thrombopoietin receptor agonist	Thrombopoietin receptor agonist
Silodosin	Rapaflo	2008	benign prostatic hyperplasia	α1-antagonist	α1-antagonist
C1 Esterase Inhibitor (Human)	Cinryze	2008	Hereditary angioedema	C1 inhibitor	C1 esterase inhibitor
Lacosamide	Vimpat	2008	epilepsy	Sodium channel inactivator	unclear (Na channel inhibitor?)
Fesoterodine	Toviaz	2008	Overactive bladder	Muscarinic antagonist	Muscarinic antagonist (multiple subtypes)
Rufinamide	Banzel	2008	Lennox-Gastaut syndrome	Triazole derivative	unclear
Eltrombopag	Promacta	2008	Thrombocytopenia	Thrombopoietin receptor agonist	Thrombopoietin receptor agonist
Tapentadol	Nucynta	2008	pain	Analgesic	µ-opioid agonist; norepinephrine reuptake inhibitor
Fospropofol	Lusedra	2008	general anesthesia	Anesthetic agent	GABA-A agonist
Plerixafor	Mozobil	2008	lymphoma, myeloma	Hematopoetic stem cell mobilizer	CXCR4 chemokine inhibitor
Degarelix	Firmagon	2008	prostate cancer	GnRH antagonist	GnRH antagonist
Milnacipran	Savella	2009	Fibromyalgia	Serotonin and norepinephrine reuptake inhibitor	Serotonin and norepinephrine reuptake inhibitor
Febuxostat	Uloric	2009	hyperuricemia	Xanthine oxidase inhibitor	Xanthine oxidase inhibitor
Everolimus	Afinitor	2009	pancreatic cancer, renal cell carcinoma, Astrocytoma	Kinase inhibitor	mTOR inhibitor
Artemether + Lumefantrine	Coartem	2009	malaria	Artemisinin-based combination therapy	Artemisinin-based combination therapy
Golimumab	Simponi	2009	Rheumatoid arthritis, Psoriatic Arthritis, Ankylosing spondylitis	Monoclonal antibody/TNFα blocker	TNFα blocker
AbobotulinumtoxinA	Dysport	2009	cervical dystonia	neurotoxin	acetylcholine release inhibitor
Iloperidone	Fanapt	2009	schizophrenia	Benzisoxazole derivative	D2/5HT2A antagonist
Tolvaptan	Samsca	2009	Hyponatremia	Arginine vasopressin antagonist	V2 receptor antagonist
Besifloxacin	Besivance	2009	bacterial conjunctivitis	Fluoroquinolone	DNA synthesis inhibitor
Canakinumab	Ilaris	2009	Muckle–Wells syndrome, familial cold autoinflammatory syndrome, neonatal-onset multisystem inflammatory disease	Monoclonal antibody/IL-1β	IL-1β inhibitor
Dronedarone	Multaq	2009	cardiac arrhythmia	Class III antiarrhythmic	Class III antiarrhythmic
Prasugrel	Effient	2009	thrombosis	Platelet aggregation inhibitor	Platelet aggregation inhibitor
Saxagliptin	Onglyza	2009	diabetes	Dipeptidyl peptidase-4 inhibitor	DPP4 inhibitor
Pitavastatin	Livalo	2009	hypercholesterolemia	HMG-CoA reductase inhibitor	HMG-CoA reductase inhibitor
Asenapine	Saphris	2009	schizophrenia	Dibenzazepine	D2/5HT2A antagonist
Vigabatrin	Sabril	2009	epilepsy	GABA analog	GABA analog
Bepotastine	Bepreve	2009	allergic conjunctivitis	H1-antagonist	histamine release inhibitor
Telavancin	Vibativ	2009	skin infections	Lipoglycopeptide antibacterial agent	bacterial cell wall synthesis inhibitor
Pralatrexate	Folotyn	2009	lymphoma	Dihydrofolic acid reductase inhibitor	Folate analog metabolic inhibitor
Ustekinumab	Stelara	2009	psoriasis	Monoclonal antibody/IL-12 and IL-23 blocker	IL-12 and IL-23 inhibitor
C1 Esterase Inhibitor (Human)	Berinert	2009	Hereditary angioedema	C1 inhibitor	C1 esterase inhibitor
Human papilloma virus vaccine	Cervarix	2009	cervical cancer	Vaccine	Vaccine
Alpha1-Proteinase Inhibitor	Prolastin-C	2009	panacinar emphysema	α1-Proteinase Inhibitor	Enzyme Replacement therapy
Pazopanib	Votrient	2009	renal cell carcinoma	Kinase inhibitor	tyrosine kinase inhibitor
Ofatumumab	Arzerra	2009	leukemia	Monoclonal antibody/CD20-blocker	B lymphocyte inhibition
Romidepsin	Istodax	2009	lymphoma	Histone deacetylase inhibitor	Histone deacetylase inhibitor
Capsaicin	Qutenza	2009	Postherpetic neuralgia	Analgesic	TRPV1 channel agonist
Ecallantide	Kalbitor	2009	hereditary angioedema	Plasma kallikrein inhibitor	Plasma kallikrein inhibitor
Tocilizumab	Actemra	2010	Rheumatoid arthritis	Monoclonal antibody/IL-6-blocker	IL-6 antagonist
Dalfampridine	Ampyra	2010	multiple sclerosis	Potassium channel blocker	Potassium channel blocker
Liraglutide	Victoza	2010	diabetes	Incretin mimetic	GLP-1 agonist
Collagenase clostridium histolyticum	Xiaflex	2010	Dupuytren's contracture	Debriding/Healing Agent	anti-collagen enzyme
Velaglucerase alfa	Vpriv	2010	Gaucher's disease	enzyme	Enzyme replacement therapy
Immune Globulin (Human)	Hizentra	2010	primary immune deficiency	Immune Globulin	unclear
Carglumic Acid	Carbaglu	2010	Hyperammonemia	Carbamoyl Phosphate Synthetase 1	enzyme activator
Polidocanol	Asclera	2010	varicose veins	Sclerosing Agent	Sclerosing Agent
Sipuleucel-T	Provenge	2010	prostate cancer	Immunomodulator	immunostimulant
Estradiol valerate + dienogest	Natazia	2010	contraception	Estrogen/progestogen combination	ovulation suppression
Alglucosidase alfa	Lumizyme	2010	Pompe disease	enzyme	Enzyme replacement therapy
Denosumab	Prolia	2010	osteoporosis	Monoclonal antibody/RANKL-blocker	osteoclast inhibitor
Cabazitaxel	Jevtana	2010	prostate cancer	Antimicrotubule agent	mitotic inhibitor
Alpha1-Proteinase Inhibitor (Human)	Glassia	2010	emphysema	enzyme	Enzyme replacement therapy
Alcaftadine	Lastacaft	2010	allergic conjunctivitis	H1-antagonist	histamine release inhibitor
incobotulinumtoxinA	Xeomin	2010	cervical dystonia, Blepharospasm	neurotoxin	acetylcholine release inhibitor
Ulipristal	Ella	2010	contraception	Emergency contraceptive	selective progesterone receptor modulator
Pegloticase	Krystexxa	2010	gout	Recombinant urate-oxidase enzyme	uric acid conversion enhancer
Fingolimod	Gilenya	2010	multiple sclerosis	Sphingosine 1-phosphate receptor modulator	Sphingosine 1-phosphate modulator
Dabigatran	Pradaxa	2010	stroke	Thrombin inhibitor	direct thrombin inhibitor
Lurasidone	Latuda	2010	schizophrenia	Benzoisothiazol derivative	D2/5HT2A antagonist
Ceftaroline	Teflaro	2010	broad-spectrum infections	Cephalosporin	bacterial cell wall synthesis inhibitor
Tesamorelin	Egrifta	2010	lipodystrophy	Growth hormone-releasing factor	growth hormone release-stimulating peptide
Eribulin	Halaven	2010	breast cancer	Antimicrotubule agent	mitotic inhibitor
Spinosad	Natroba	2011	head lice	Pediculocide	nicotinic acetylcholine receptor activator
Vilazodone	Viibryd	2011	depression	SSRI	5-HT1A partial agonist
Factor XIII	Corifact	2011	Factor XIII deficiency	Plasma glycoprotein	fibrin cross-linker
Azilsartan	Edarbi	2011	hypertension	Angiotensin II receptor antagonist	angiotensin II receptor antagonist
Roflumilast	Daliresp	2011	COPD	PDE4 inhibitor	PDE4 inhibitor
Belimumab	Benlysta	2011	lupus	Monoclonal antibody/BLyS blocker	BLyS blocker
Ipilimumab	Yervoy	2011	melanoma	Monoclonal antibody/CTLA-4 blocker	T-cell activation through CTLA-4 blockade
Vandetanib	Caprelsa	2011	thyroid cancer	Kinase inhibitor	tyrosine kinase inhibitor
Gabapentin enacarbil	Horizant	2011	Restless Legs Syndrome	GABA analog	GABA analog
Abiraterone	Zytiga	2011	prostate cancer	Nonsteroidal antiandrogen	CYP17A1 inhibitor
Linagliptin	Tradjenta	2011	diabetes	Dipeptidyl peptidase-4 inhibitor	DPP4 inhibitor
Boceprevir	Victrelis	2011	hepatitis C	Protease inhibitor	NS3/4A protease inhibitor
Rilpivirine	Edurant	2011	HIV	Non-nucleoside reverse transcriptase inhibitor	Non-nucleoside reverse-transcriptase inhibitor
Telaprevir	Incivek	2011	hepatitis C	Protease inhibitor	NS3/4A protease inhibitor
Fidaxomicin	Dificid	2011	C. difficile	Macrolide	RNA polymerase inhibitor
Ezogabine	Potiga	2011	epilepsy	Potassium channel opener	Potassium channel opener
Belatacept	Nulojix	2011	Graft Rejection	Selective costimulation modulator	CTLA4-Ig agonist
Azficel-T	LaViv	2011	Smoothing nasolabial fold wrinkles in adults	Autologous dermal fibroblasts	unclear
Indacaterol	Arcapta	2011	COPD	β2-agonist	bronchodilator
Rivaroxaban	Xarelto	2011	deep vein thrombosis	Specific factor Xa inhibitor	Specific factor Xa inhibitor
Ticagrelor	Brilinta	2011	acute coronary syndrome (prevention of thrombotic events)	Platelet aggregation inhibitor	P2Y12 platelet inhibitor
Vemurafenib	Zelboraf	2011	melanoma	Kinase inhibitor	tyrosine kinase inhibitor
Centruroides (Scorpion) Immune F(ab')2 (Equine) Injection	Anascorp	2011	scorpion envenomation	antivenom	immunoglobulin G
Brentuximab Vedotin	Adcetris	2011	lymphoma	conjugated monoclonal antibody	conjugated immunotoxin
Icatibant	Firazyr	2011	hereditary angioedema	Bradykinin B2 antagonist	Bradykinin B2 antagonist
Crizotinib	Xalkori	2011	lung cancer	Kinase inhibitor	tyrosine kinase inhibitor
Deferiprone	Ferriprox	2011	thalassemia	Iron-chelating agent	iron sequestration
Clobazam	Onfi	2011	Lennox-Gastaut syndrome	Benzodiazepine	GABA-A agonist
Ruxolitinib	Jakafi	2011	Myelofibrosis	Kinase inhibitor	Janus kinase inhibitor
Asparaginase Erwinia chrysanthemi	Erwinaze	2011	acute lymphoblastic leukemia	enzyme	asparagine converting enzyme
Aflibercept	Eylea	2011	macular degeneration	VEGF inhibitor	VEGF-A and PlGF inhibitor
Glucarpidase	Voraxaze	2012	methotrexate toxicity	enzyme	methotrexate inactivation
Ingenol	Picato	2012	actinic keratosis.	unclear	unclear
Axitinib	Inlyta	2012	renal cell carcinoma	Kinase inhibitor	tyrosine kinase inhibitor
Vismodegib	Erivedge	2012	basal cell carcinoma	Hedgehog pathway inhibitor	SMO inhibitor
Ivacaftor	Kalydeco	2012	cistic fibrosis	CFTR potentiator	CFTR potentiator
Tafluprost	Zioptan	2012	glaucoma	prostaglandin analog	prostaglandin analog
Lucinactant	Surfaxin	2012	respiratory distress syndrome	pulmonary surfactant	pulmonary surfactant
Peginesatide	Omontys	2012	anemia due to chronic kidney disease	erythropoiesis-stimulating agent	erythropoietin receptor activator
Avanafil	Stendra	2012	erectile dysfunction	PDE5 inhibitor	PDE5 inhibitor
Taliglucerase alpha	Elelyso	2012	Gaucher disease	enzyme	Enzyme replacement therapy
Pertuzumab	Perjeta	2012	breast cancer	Monoclonal antibody/HER2-blocker	HER2/neu receptor antagonist
Lorcaserin	Belviq	2012	obesity	5-HT 2C agonist	5-HT2C receptor agonist
Mirabegron	Myrbetriq	2012	Overactive bladder	Adrenergic/anticholinergic agent	β3 adrenergic agonist
Sodium picosulfate, magnesium oxyde, citric acid	Prepopik	2012	colon cleansing and preparation	Bowel cleanser	peristalsis stimulator
Carfilzomib	Kyprolis	2012	multiple myeloma	Proteasome inhibitor	Proteasome inhibitor
Aclidinium	Tudorza Pressair	2012	COPD	Anticholinergic bronchodilator	M3 muscarinic acetylcholine antagonist
Icosapent	Vascepa	2012	hypertriglyceridemia	Lipid-regulating agent	unclear
Ziv-aflibercept	Zaltrap	2012	colorectal cancer	VEGF inhibitor	VEGF-A inhibitor; VEGF-B inhibitor; PIGF inhibitor
Elvitegravir; Cobicistat; Emtricitabine; Tenofovir	Stribild	2012	HIV	HIV integrase strand transfer inhibitor/nucleoside analogue combination	mixture of 4 known MoAs
Linaclotide	Linzess	2012	IBS; constipation	Guanylate cyclase-C agonist	Guanylate cyclase-C agonist
Enzalutamide	Xtandi	2012	prostate cancer	Nonsteroidal antiandrogen	androgen receptor inhibitor
Bosutinib	Bosulif	2012	leukemia	Kinase inhibitor	tyrosine kinase inhibitor
Teriflunomide	Aubagio	2012	multiple sclerosis	Pyrimidine synthesis inhibitor	dihydroorotate dehydrogenase inhibitor
Regorafenib	Stivarga	2012	colorectal cancer	Kinase inhibitor	tyrosine kinase inhibitor
ocriplasmin	Jetrea	2012	Vitreomacular Adhesion	protease	proteolysis
Perampanel	Fycompa	2012	epilepsy	AMPA receptor antagonist	AMPA receptor antagonist
Omacetaxine	Synribo	2012	leukemia	protein synthesis inhibitor	protein synthesis inhibitor
Tofacitinib	Xeljanz	2012	rheumatoid arthritis	Kinase inhibitor	Janus kinase inhibitor
Cabozantinib	Cometriq	2012	thyroid cancer	Kinase inhibitor	tyrosine kinase inhibitor
Ponatinib	Iclusig	2012	leukemia	Kinase inhibitor	tyrosine kinase inhibitor
Raxibacumab	Raxibacumab	2012	anthrax	Monoclonal antibody/PA antigen-blocker	B Anthracis' Protective antigen antagonist
Pasireotide	Signifor	2012	Cushing’s disease	somatostatin analog	somatostatin receptor 5 agonist
Teduglutide	Gattex	2012	Short Bowel Syndrome	GLP-2 analog	GLP-2 analog
Lomitapide	Juxtapid	2012	Homozygous familial hypercholesterolemia	MTP inhibitor	microsomal triglyceride transfer protein (MTP) inhibitor
Apixaban	Eliquis	2012	Stroke	Specific factor Xa inhibitor	Specific factor Xa inhibitor
Bedaquiline	Sirturo	2012	Tuberculosis	diarylquinoline	ATP synthase inhibitor
Crofelemer	Fulyzaq	2012	Diarrhea	CFTR and CaCC inhibitor	CFTR and CaCC inhibitor